期刊文献+

系统性红斑狼疮的治疗进展

下载PDF
导出
摘要 系统性红斑狼疮(SLE)是一多因素参与的特异性的自身免疫病,病因目前不明。自从糖皮质激素与免疫抑制剂被用于治疗 SLE 之后,SLE 患者的预后已经有明显改善。但是,SLE 的治疗现状仍不容过分乐观。首先目前仍然有约10%的患者在发病5年内死亡;其次由于疾病的进展及一些治疗带来的副作用,尤其是细胞毒药物及糖皮质激素的应用,SLE 患者的平均寿命明显短于正常人群。不少学者明确指出,50%重症狼疮性肾炎(LN)
出处 《中国医学文摘(内科学)》 2004年第4期540-543,共4页 China Medical Abstracts
  • 相关文献

参考文献4

二级参考文献22

  • 1Van Brubben MC J, Wrlgrcen B, Rijke RPM, et al. Heparin and heparinoids prevent the binding of immune complexes containing nuclesomal antigens to the GBM and delay nephritis in MRL/lpr mice. Kidney Int ,1996, 50:1555-1564.
  • 2Wang Y,Hu O,Madre JA.Amelioration of lupus-like autoimmune disease in NZB/W F 1 mice after treatment with a blocking monoclonal antibody specific for complement component C5. Proc Natl Acad Sci USA, 1996, 93:8563-8568.
  • 3Charles PJ, Smeenk RJT, Dejong J, et al. Assessment of antibodies to double-stranded DNA induced in rheumatoid arthritis patients following treatment with infliximab, a monoclonal antibody to tumor necrosis factor alpha:findings in open-label and randomiz
  • 4Sato EI,Assis LS,Lourenzi VP,et al. Long-term thalidomide use in refraetory cutaneous lesions of systemic lupus erythermatosus. Rev Assoc Med Bras, 1998,44:289-293.
  • 5Clynes R,Dumitru C,Ravetch JV.Uncoupling of immune complex formation and kidney damage in autoimmune glomerulonephritis. Science, 1998,279:1052-1054.
  • 6Balomenos D,Rumold R,Theofilopoulos AN.Interferon-gamma is required for lupus-like disease and lymphoaccumulation in MRL-lpr mice.J Clin Invest, 1998,101:364-371.
  • 7Alvarez NYJ, Cobrarrubias CA, Escalante TF, et al. Bromocriptine in systemic lupus erythematosus: a double-blind randomized, placebo-controlled study. Lupus ,1998, 7:414-419.
  • 8Van Vollenhoven RF, Park JL, Genovese MC, et al. A double-blind,placebo-controlled, clinical trial of dehydrcepiandrosterone in severe systemic lupus erythematosus. Lupus, 1999,8:181 - 187.
  • 9Blanco R, Martinez VM, Redriguezvalverde V, et al. Successful therapy with danazol in refractory autoimmune thrombocytopoenia associated with rheumatic diseases. Br J Rheumatol,1997, 36:1095-1099.
  • 10Levy Y, Sherer Y, Ahmed A, et al. A study of 20 SLE patients with intravenous immunoglobulin - clinical and serologic response. Lupus,1999, 8:705-712.

共引文献67

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部