胆道闭锁患儿血清sICAM-1与IL-18的变化及临床意义

Changes of sICAM-1 and IL-18 in sera of the children with biliary atresia and its clinical significance

目的 研究可溶性细胞间粘附分子 1(sICAM 1)、白细胞介素 18(IL 18)在胆道闭锁(BA)发病机制中的作用及临床意义。方法 胆道闭锁患儿 2 1例 ,男 8例 ,女 13例 ;年龄 2个月～ 12岁 ,所有患儿诊断均经手术后病理切片证实。正常对照 12例为健康体检儿童 ,年龄 1个月～ 10岁。采用ELISA法动态测定胆道闭锁患儿手术前、后血清sICAM 1、IL 18水平。结果 胆道闭锁患儿血清sICAM 1、IL 18水平明显高于健康对照组 ,且两者呈正相关。Kasai手术后两者水平比术前无明显下降 ,且黄疸越重 ,水平越高。结论 sICAM 1、IL 18参与胆道闭锁的进行性损伤的病理过程 ,手术后两者增高表明外科手术不能完全阻止BA的炎症 。

Objective To investigate the changes of serum sICAM-1 and IL-18 levels in patients with biliary atresia (BA).Methods Twenty-one patients (8 boys and 13 girls) with BA with their ages ranged from 2 months to 12 years were studied. The BA was confirmed at operation and histological examination on the resected portal tissue. Twelve children whose ages ranged from 1 month to 10 years were studied as a control. Their serum levels of sICAM-1 and IL-18 were measured by ELISA. In BA patients, the pre- and post-o...