隐孔菌多糖对慢性阻塞性肺疾病大鼠肺功能和气道炎症的影响

Effect of Cryptoporus Polysaccharides on Lung Function and Airway Inflammation in Rats with Chronic Obstructive Pulmonary Diseases

目的观察隐孔菌多糖(CVPs)对慢性阻塞性肺疾病(COPD)大鼠肺功能和气道炎症的影响。方法采用反复气管内注入脂多糖(LPS)和木瓜蛋白酶构建 COPD 大鼠模型,并用 CVPs 治疗,观察各组大鼠的肺功能、支气管肺泡灌洗液(BALF)中炎症细胞的变化及其相关性。结果模型组与对照组比较,气道阻力(R_L)显著增高、动态肺顺应性(C_(dyn))显著降低,BALF 中炎症细胞总数、中性粒细胞、淋巴细胞、单核/巨噬细胞均显著增高(P<0.01)。CVPs 干预可使用药组的肺功能和 BALF 中炎症细胞都呈现具有量效关系的改善。其对用药组 BALF 中炎症细胞总数的抑制作用与 R_L 降低呈正相关(P<0.01),而对淋巴细胞的抑制作用与C_(dyn)降低呈负相关(P<0.01)。结论 CVPs 可通过抑制气道炎症改善 COPD 大鼠的肺功能。

Objective To observe the effect of cryptoporus polysaccharides (CP) on lung function and airway inflammation in rats with chronic obstructive pulmonary diseases (COPD).Methods Rats were managed by repeated intra-tracheal ad- ministration with lipopolysaccharide and papain to establish the model of COPD and treated with CP.Changes of pul- monary resistance (R_L),dynamic compliance (C_(dyn)) and the accumulation of inflammatory cells in bronchoalveolar lavage fluid (BALF) in various groups were observed and t...