严重急性呼吸综合征临床病理研究

The study of SARS in clinic and pathology

目的 探讨SARS的病理形态学特点。方法 常规HE染色,光镜观察。免疫组化S-P法检测3例SARS患者的肺组织CK、CD34、Ⅳ型胶原、CD 68、Mac 387的表达。结果 SARS病理形态表现为肺泡上皮广泛破坏,Ⅱ型上皮细胞增生。肺泡壁毛细血管内皮细胞肿胀。大部分肺泡腔及肺泡管内透明膜形成。间质有较多的炎症细胞浸润,纤维母细胞增生。结论 SARS是一种伴透明膜形成的急性非特异性间质性肺炎。

Objective To investigate the pathologic morphological character of SARS. Methods Routine H - E stainning, observed under light microscope. The expression of CK,CD34,IV colleger,CD68,Mac387 in lung lesions from 3 SARS patients were studied with S- P immunohistochemical technique. Results Pathologic morphological character of SARS are as follows: pulmonary alveoli epithelium were destroyed extensively, type II alveolar cell hyperplasia. The capillary vessel endothelium of alveolar wall were swelling, hyaline membrane formed in most of pulmonary alveoli cavity and alveolar duct. Much inflammation cell invaded, fibroblast hyperplasia. Conclusion SARS is an actue non- specific interstitial pneumonia,going with hyaline membrane formation.