SARS患者血清C3,C4,PA和CRP的定量检测

Determination of complement 3, complement 4, prealbumin and C - reactive protein in serum of SABS patients

目的 探讨血清中补体C3、C4、前白蛋白(PA)和C反应蛋白(CRP)的检测对SARS诊断的价值。方法透射比浊法检测临床诊断SARS患者54例、其他肺炎患者20例及30例正常体检者血清中C3、C4、PA和CRP的含量。结果 与对照组[C4(0.38±0.26)g/L,CBP(0.42±0.26)mg/L,PA(376.2±74.08)mg/L]及肺炎组[C4(0.57±0.31)g/L,CRP(0.88±0.43)mg/L,PA(290.9±76.48)mg/L]比较,临床诊断SARS患者组[C4(1.15±0.56)g/L,CRP(10.52±8.77)mg/L,PA(106.8±34.2)mg/L],PA明显降低,C4和CRP则明显升高,差异有显著性(P<0.01);各组C3之间差异无显著性(P>0.05)。结论 检测C4,PA和CRP有助于SARS的早期鉴别诊断。

Objective To study the value of the examination of serum complement 3(C3) , complement 4(C4) , prealbumin (PA) and C- reative protein(CRP) in the SABS patients for the distinctive diagnosis.Methods The concentration of C3, C4, PA and CRP were determined by turbidimetry in serum of 54 SARS, 20 pneumonia and 30 normals. Results (1)The concentration of C4 and CRP in serum of SARS patients[C4(1.15 ±0.56)g/L,CRP(10.52±8.77)mg/L]were higer(P< 0.01) than that in pneumonia [C4(0.57±0.31) g/L, CRP(0.88+0.43)mg/L] and control[C4(0.38±0.26)g/L,CRP(0.42±0.26)mg/L]. PA was lower with statistically significant difference( P < 0.01) . No C3 difference found in three groups( P > 0.05) . Conclusion The examination of C4 CRP and PA in serum of SARS patient is beneficial to make distinctive diagnosis at early stage