多发伤患者外周血中白介素-12的动态变化以及与APACHEⅡ评分相关性研究

The Change of Interleukin-12 level in Peripherl Blood of Patients with Multiple injury and the Correlation with Acute Physiology and Chronic Health EvaluationⅡ

目的 探讨多发伤患者外周血中白介素-12的动态变化以及与APACHEⅡ评分的相关性。方法 采用酶联免疫分析法测定32例多发伤患者及12例健康体者的血浆白介素-12水平,同时对32例多发伤患者进行APACHEⅡ评分。结果 多发伤患者血浆IL-12水平在各个时短均显著高于正常对照组(P<0.05);多发伤患者中合并多脏器功能障碍综合征(MODS)者血浆IL-12水平显著高于未合并MODS者(P<0.05);APACHEⅡ评分与血浆IL-12达到峰值的水平呈显著正相关(r=0.728,P<0.05)。结论 外周血中IL-12的水平变化可作为多发伤严重程度和判定患者是否合并MODS的指标之一;多发伤患者血浆IL-12水平与APACHEⅡ评分有良好的相关性,测定IL-12水平有助于判断预后。

Objective To detect The change of interleukin-12 level in peripherl blood of patientswith multiple injury and the correlation with Acute physiology and chronic health evaluation Ⅱ.Methods Plasma IL-12 level were measured using enzyme linked immunoabsorbent assay (ELASA) and APACHEⅡscore were also assessed in 32 patients with multiple injury. Results IL-12 level of patients withmultiple injury were significantly higher than control group on days 1,3,7,12during hospitalization(P<0.05). The level of IL-12 in patients complicated with MODS were significantly increased than non-MODSgroup(P<0.05). The peak level of IL-12 were closely correlated with APACHEⅡscore(P<0.05). Conclu-sion The change of IL-12 can judge the prognosis of patients with multiple injury and complicatingof MODS.Key words Interleukin-12 Multiple injury Multiple organ dysfunction syndrome Acutephysiology and chronic health evaluation Ⅱ(APACHEⅡ) 中图分类号:R641;R331.142 文献标识码:A 文章编号:1007-1245(2003)12-0011-03The Change of Interleukin-12 level in Peripherl Blood ofPatients with Multiple injury and the Correlation with AcutePhysiology and Chronic Health EvaluationⅡRao JingjieHeshun Hospital of Nanhai,Guangdong,528241Abstract Objective To detect The change of interleukin-12 level in peripherl blood of patientswith multiple injury and the correlation with Acute physiology and chronic health evaluation Ⅱ.Methods Plasma IL-12 level were measured using enzyme linked immunoabsorbent assay (ELASA) and APACHEⅡscore were also assessed in 32 patients with multiple injury. Results IL-12 level of patients withmultiple injury were significantly higher than control group on days 1,3,7,12during hospitalization(P<0.05). The level of IL-12 in patients complicated with MODS were significantly increased than non-MODSgroup(P<0.05). The peak level of IL-12 were closely correlated with APACHEⅡscore(P<0.05). Conclu-sion The change of IL-12 can judge the prognosis of patients with multiple injury and complicatingof MODS.