DA方案与α干扰素序贯治疗成人急性非淋白血病的疗效分析

Analysis of Effectiveness of DA Regimen Adding Interferon-αon Adult Acute Norlymphoblastic Leukemia

目的 观察DA方案与α干扰素序贯治疗成人ANLL 初治患者中的治疗效果,并与传统治疗方案(DA)进行比较。方法 对诊断明确者随机分为治疗组(DA+α干扰素组)和对照组(DA组),1疗程后,2疗程后分别评价疗效。结果 治疗组1疗程达CR为80%; 2疗程总CR为90%,总有效率为95%。对照组1疗程达CR为50%, 2疗程总CR为59.1%,总有效率为72.7%。两组相比治疗组的血小板抑制作用强于对照组。结论 DA+α干扰素诱导治疗ANLL其CR率显著优于DA方案,对解决再生耐药具有实用价值。

Objective To observe the effect of DA regimen adding Interferon-α in untreatedpatients who were adult ANLL, and compared with DA regiment. Method The patients were randomlyseparated into two groups. One group was treaded with DA regimen adding Interferon-α (the therapeuticgroup), the other with DA regimen (the control group). The effect of the two groups were compared afterbeing treated one period of treatment and two periods of treatment. Result In the therapeutic group,the CR rate after being treated one period of treatment was 80%; the CR rate after being treated twoperiods of treatment was 90%. The thrombocyte depression was more serious in the therapeutic group thanthat in the control group. Conclusion The CR rate of therapeutic group was obviously more than therate of control group. It was value in solution to regenerated drug-resistance .