Baylis-Hillman Reaction Involving Substituted Cyclic Enones in Aqueous Media

β-Substituted enones have been considered less reactive in Baylis-Hillman reaction. The reaction of cyclicenones is sluggish or does not occur at all under traditional conditions. [1] Therefore, substituted cyclic enones havebeen less explored in Baylis-Hillman reaction due to the extremely low reactivity. In this communication, we reported Baylis-Hillman reaction of substituted cyclic enones using our previously developed conditions with imidazole as catalyst. The reaction proceeded smoothly in aqueous media affording the desired product with good yields and moderate diastereoselectivity.……