Efficient Synthesis of the Oxadiazole Biphenyl Tetrazoles

Efficient Synthesis of the Oxadiazole Biphenyl Tetrazoles

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摘要 Since the discovery of losartan[1](DUP 753), the leading non-peptide AT1 antagonist, several highly potent AT1 selective antagonists bearing heterocycles have been reported. [2] The tetrazole group is a common acidic functionpresent in many these antagonists.……

作者 CHAO Shu-Jun QIU Zao-Zao HUI Xin-Ping XU Peng-Fei ZHENG Rong-Liang

机构地区 State Key Laboratory of Applied Organic Chemistry Life School

出处《有机化学》 SCIE CAS CSCD 北大核心 2003年第z1期420-421,共2页 Chinese Journal of Organic Chemistry

分类号 O62 [理学—有机化学]

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1[1]Carini, D. J.; Dunica, J. V.; Aldrich, P. E.; Chiu, A. T.; Johnson, A. L.; Pierce, M. E. et al. J. Med. Chem. 1991, 34, 2525.
2[2]Ellingboe, J. W.; Collini, M. D.; Quagliato, D.; Chem, J.; Antsne, M.; Schmid, J. et al. J. Med. Chem. 1998, 41, 4251.
3[3]Reid, J. R.; Heindel, N. D. J. Heterocycl. Chem. 1976, 13, 925.

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Efficient Synthesis of the Oxadiazole Biphenyl Tetrazoles

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