New Eremophilane Sesquiterpenes from Cacalia ainsliaeflora

Cacalia ainsliaeflora, a compositae distributed in the west of China, has long been used as Chinese traditional medicine for invigorating the circulation of blood, curing pellagra, rheumatismal edema and as an insecticide. [1] We recently reported the isolation and identification of five eremophilane sesquiterpenes from this plant. [2] In our continuing research on the bioactive constituents from Cacalia species, we reinvestigated the chemical constituents of the roots of C. ainsliaeflora. As a result, seven new eremophilane sesquiterpenes (2 ～ 8), and a known erempphilanolide (1) were isolated. Their structures were elucidated by spectroscopic methods.……