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First Synthesis of 3'- Geranyl-2', 3,4,4'-tetrahydroxychalcone with 5 α- Reductase Inhibitory Properties

First Synthesis of 3'- Geranyl-2', 3,4,4'-tetrahydroxychalcone with 5 α- Reductase Inhibitory Properties
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摘要   The geranylated chalcone 1,3′-geranyl-2′, 3,4,4′-tetvahydroxychalcone with high 5α-reductase inhibitory prop erties, was isolated from Artocarpus incisus by Shimizu in 2000. [1] Herein, we describe the first synthesis of the natural product 1 by four steps starting from compounds 2 and 7. The synthetic route was shown in Scheme 1:……
出处 《有机化学》 SCIE CAS CSCD 北大核心 2003年第z1期76-76,共1页 Chinese Journal of Organic Chemistry
基金 Project supported by the National Natural Science Foundation of China (No. 20062001 ), the Science Foundation of Person Ability (No.20012205) and the Natural Science Foundation of Guangxi Province (No. 0007016).
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  • 1[1]Shimzu, K. et al. Phytochemistry 2000, 54, 737.

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