稳定性同位素示踪测定NaFeEDTA强化酱油中铁在人体中吸收率

Study on iron absorption of NaFeEDTA in human body with stable isotope method

采用铁稳定性同位素54Fe和58Fe分别标记FeSO4及NaFeEDTA并以稀土元素 (Dy)作为排泄物回收标记物。自愿受试人群为 18～ 2 2岁健康女性。采用我国典型城镇成年女性膳食模式。两种铁剂及Dy以酱油为食物载体一同分 2日 6次经口给入。实验其间每日留取受试人膳食样品并完全收集受试人在实验期的排泄物。采用原子吸收和ICP -MS分别检测膳食及排泄物中总铁含量和铁同位素比例 ,对两种铁剂中的铁的吸收率进行比较。结果表明 ,FeSO4中铁在人体中的平均吸收率为 4 73% ,NaFeEDTA为 10 5 1%。二者差异为极显著(P <0 0 1)。说明NaFeEDTA中铁的吸收率优于FeSO4。

The absorption of iron from NaFeEDTA and FeSO_4 was studied in 10 female volunteer subjects, aged 18～22 y. Stable iron isotopes 54 Fe and 58 Fe used as tracers labeled FeSO_4 and NaFeEDTA respectively. Dy was used as a marker of the iron recovery. The dietary pattern of the study was clustered from the typical dietary pattern of Chinese Township adult women based on the national nutrition survey. Soy sauce as the food vehicle of 54 FeSO_4 and Na 58 FeEDTA and Dy was orally administrated three times a day in two days. The diet samples and feces of subjects were collected in 15 days. AA and ICP-MS were used for the iron content and stable iron ratio analysis of the samples. The result showed that absorption of 54 Fe and 58 Fe were 4.73% and 10.51% respectively ( P <0.01). This result suggested that the iron absorption in NaFeEDTA was higher than that of FeSO4 in the typical dietary pattern of Chinese Township adult women.