NaFeEDTA强化酱油对铁缺乏的防治效果——人群干预试验

Studies on the effectiveness of NaFeEDTA fortified soy sauce in controlling iron deficiency—a population-based intervention trial

在过去研究人体铁吸收率和对贫血儿童的治疗试验的基础上 ,观察NaFeEDTA强化酱油在自然高危人群中纠正铁缺乏的效果及可接受性。在贵州省毕节市海子街镇用双盲安慰剂对照法 ,在 14 0 0 0名 3岁以上人群中进行为期 18个月的NaFeEDTA强化酱油 (Fe 2 96mg铁 L)干预试验。观察指标包括 :血红蛋白、红细胞压积、血浆铁蛋白和维生素A、膳食、体格测量、智力发育和身体耐力。干预组平均每人每天消费 16 5ml酱油 ,其中含 4 9mg来自NaFeEDTA的铁。与对照人群相比 ,干预人群中各年龄 -性别组的血红蛋白水平明显升高、贫血率明显下降、血浆铁蛋白明显升高 ;3～ 6岁儿童身高和体重明显改善。而同时 ,两组食物消费与试验前无明显差别。NaFeEDTA强化酱油对于纠正铁缺乏、降低贫血率以及改善儿童生长发育有明显效果。同时 ,试验参加者一致反映铁强化酱油的感官性状良好 ,可接受性良好。

To study the effectiveness of NaFeEDTA fortified soy sauce in controlling iron deficiency in high risk populations, based on the previous research on the iron availability of NaFeEDTA fortified soy sauce in humans and its therapeutic effects in anemic children. To conduct a 18-month randomized placebo-controlled intervention trial in 14000 residents (>3 year-old) in Bijie city of Guizhou province, using NaFeEDTA fortified soy sauce (Fe 296 mg/L). Study parameters included: hemoglobin, hematocrit, plasma ferritin and retinol, food consumption, anthropometry, mental development and physical endurance. The average soy sauce consumption of the intervened group was 16.5 ml per person per day, which contained 4.9 mg Fe from NaFeEDTA. As compared with the control group, the intervened group had significantly higher hemoglobin level, lower anemia prevalence, higher ferritin level, and higher height and weight in the 3-6 year-old group. At the same time, the food consumption of the two groups remained the same as before the trial. NaFeEDTA fortified soy sauce is significantly effective in controlling iron deficiency, reducing prevalence of iron deficient anemia and improving physical growth of children. In addition, NaFeEDTA fortified soy sauce is well accepted by the local residents.