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21世纪的航天医学细胞分子生物学 被引量：17

Cell and Molecular Biology of Space Medicine in the 21st Century.
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摘要 本文综述了航天医学细胞分子生物学的研究背景和最新进展 ,系统总结了对微重力的细胞学效应的新认识和细胞骨架等研究热点 ,并展望了该领域研究的新策略。 This paper reviewed the background and up to date progress in cell and molecular biology research in space medicine, and summarized the effects of microgravity on cells and several hotspots such as cytoskeleton. The new strategies of study in the 21st century is also discussed.
作者 李莹辉
机构地区 航天医学工程研究所
出处 《航天医学与医学工程》 CAS CSCD 北大核心 2003年第z1期588-592,共5页 Space Medicine & Medical Engineering
基金 中国载人航天工程基金资助
关键词 航天医学 细胞分子生物学 微重力 细胞骨架 信号转导 space medicine cell molecular biology microgravity cytoskeleton signal transduction
分类号 R854 [医药卫生—航空、航天与航海医学]
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  • 1熊江辉,李莹辉,聂捷琳.Effects of simulated microgravity on nitric oxide level in cardiac myocytes and its mechanism[J].Science China(Life Sciences),2003,46(3):302-309. 被引量：7
  • 2Yamamoto K,Dang QN,Kelly RA,et al.Mechanical strain suppresses inducible nitric oxide synthase in cardiac myocyte[].Journal of Biological Chemistry.1998
  • 3Kaasik A,M inajeva A,DeSousa E,et a.l N itric oxideinh ib its card iac energy production via inh ib ition ofm itochondrial creatine k inase[].FEBS Letters.1999
  • 4SinghK,BalligandJ.L,FischerT .A .etal.Regulationofcy tokine induciblenitricoxidesynthaseincardiacmyocytesandmi crovascularendothelialcells.Roleofextracellularsignal regulatedkinases1and2(ERK1/ERK2)andSTAT1alpha[].Journal of Biological Chemistry.1996
  • 5Thomas M,Mckenna,Li SH,et al.PKC mediates LPS and phorbol induced cardiac cell nitric oxide synthase activity and hypocontractility[].American Journal of Physiology.1995
  • 6Kopnisky K L,Sumners C.Angiotensin Ⅱ-induced decrease in expression of inducible nitric oxide synthase in rat astroglial cultures: role of protein kinase C[].Journal of Neurochemistry.2000
  • 7Obadia J F,Ovize M,Maupoil V. et al.Beneficial actions of preconditioning and stretch on postischemic contractile function of isolated working rat heart: effects of staurosporine[].Journal of Cardiovascular Pharmacology.1997
  • 8Goldstein MA,Edwards RJ,Schroeter JP.Cardiac morphology after conditions of microgravity during COSMOS 2044[].Journal of Applied Physiology.1992
  • 9Kojda G,Kottenberg K.Regulation of basal myocardial function by NO[].Cardiovascular Research.1999
  • 10Joe EK,Schussheim AE,Longrois D,et al.Regulation of cardiac myocyte contractile function by inducible nitric oxide synthase (iNOS): mechanisms of contractile depression by nitric oxide[].Journal of Molecular and Cellular Cardiology.1998

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航天医学与医学工程
2003年 第z1期

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