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美托拉宗的电子轰击质谱研究

Study on Metolazone Using Electrospray Ionization Mass Spectrometry
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摘要   美托拉宗(Metolazone)是一种中效利尿药,于1967年由Shetty等[1]首先合成,为噻唑啉类衍生物,是临床上常见的抗高血压药物[2],药效和噻嗪类同利尿药,但其排钠利尿作用是喹乙宗和氢氯噻嗪的10倍,另外使用时不影响氢离子和氨的分泌,血氨降低,对肾功能不全病人比其他药物略胜一筹[3,4].本工作对美托拉宗的电子轰击质谱进行了裂解研究,得到了一些质谱特征.……
出处 《质谱学报》 EI CAS CSCD 2003年第z1期73-74,共2页 Journal of Chinese Mass Spectrometry Society
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