期刊文献+

液相色谱-串联质谱法快速测定人体血浆中替米沙坦 被引量:1

Rapid Determination of Telmisartan in Human Plasma by Liquid Chromatograph-Tandem Mass Spectrometry
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摘要   替米沙坦为非肽类血管紧张素Ⅱ(AT1型)受体拮抗剂,临床上用于高血压症的治疗[1].有关生物样品中替米沙坦的测定方法有自动柱切换高效液相色谱结合荧光检测法[2]和C14放射性标记[3]等.本工作旨在建立快速、灵敏的LCMS/MS法测定人体血浆中的替米沙坦,以研究该药在受试者体内的药物动力学特点.……
出处 《质谱学报》 EI CAS CSCD 2003年第z1期111-112,共2页 Journal of Chinese Mass Spectrometry Society
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参考文献3

  • 1[1]McClellan K J, Markham A. Telmisartan [J].Drugs, 1998,56(6):1 039.
  • 2[2]Stangier J, Su CA, Brickl R, et al. Pharmacokinetics of Single-dose Telmisartan 120mg Given During and Between Hemodialysis in Subjects With Severe Renal Insufficiency: Comparison With Healthy Volunteers [J]. J Clin Pharmacol, 2000 , 40(12 Pt 1):1 365~1 372.
  • 3[3]Stangier J, Schmid J, Turck D, et al. Absorption, Metabolism, and Excretion of Intravenously and Orally Administered [14C] Telmisartan in Healthy Volunteers[J]. J Clin Pharmacol, 2000,40(12 Pt 1):1 312~1 322.

同被引文献4

  • 1熊玉卿,李新华,黄鹏,张会杰,徐文炜.替米沙坦在中国健康志愿者体内的药代动力学特征[J].中国药理学通报,2004,20(9):1038-1041. 被引量:15
  • 2Stangier J, Schmid J, Turck D, et al. Absorption, metabolism and excretion of intravenously and orally administered [ 14C ] telmisartan in healthy volunteers [ J ]. J Clin Pharmacol, 2000, 40 ( Suppl ):S1312- S1322.
  • 3Stangier J, Su CA, Brickl R, et al. Pharmacokinetics of single-dose telmisartan 120mg given during and between hemodialysis in subjects with severe renal insufficiency: comparison with healthy volunteers [J]. J Clin Pharmacol, 2000,40(Suppl): S1365 - S1372.
  • 4赵志刚,高晨,欧阳冬生,张立杰,李冬梅,徐小军,王景田.替米沙坦片人体生物等效性[J].中国临床药理学杂志,2003,19(5):348-351. 被引量:12

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