染料木黄酮在Beagle犬体内的药代动力学

Pharmacokinetics of genistein in Beagle dogs

目的 研究染料木黄酮 (genistein)在Beagle犬体内的药代动力学。方法 染料木黄酮ig后用反相高效液相色谱法测定犬血浆、尿及粪便中原型药物浓度 ,血浆药物浓度 时间数据用 3P97药代动力学软件分析。 结果Genistein在Beagle犬体内的代谢符合一室模型 ,ig后 0 2 9h达药峰浓度 ,T1 2Ke为 0 5 2h。给药后 2 4h内有 10 79%的原型药物由尿排出 ,2 1 5 5 %的原型药物由粪便排出。 6 0h内有 13 0 0 %的原型药物由尿排出 ,有 5 2 4 6 %的原型药物由粪便排出。结论 Beagle犬ig染料木黄酮后吸收迅速 ,血浆中药物的消除速度快 。

Aim To study the pharmacokinetics of genistein in Beagle dogs. Methods Genistein, suspended in 0 5% CMC Na solution, was orally administered to Beagle dogs at the dose of 5 34 mg·kg -1 . At various time intervals, 1 5 mL of blood was drawn from the vein of dogs in their front legs. At the same time, urine and feces were collected. After the collection, the feces were homogenized with physiological saline (to 1 g feces, 10 mL physiological saline were added). The genistein in plasma, urine and homo...