盐酸西替利嗪的NMR研究

NMR studies on cetirizine hydrochloride

目的 研究盐酸西替利嗪在DMSO d6溶剂中的核磁共振现象并对其质子和碳信号进行归属。方法 测定其在不同温度和加入重水条件下的各种 1D和 2D核磁共振谱。结果 室温下以DMSO d6为溶剂时 ,哌嗪环及与其N原子相连的碳、氢信号均呈现多个峰或宽峰 ,提高温度或加入重水后 ,其碳、氢信号均出现“合并”或变窄现象。结论 室温下在DMSO d6溶剂中 ,与核磁共振“时间尺度”相比 ,不同构象的盐酸西替利嗪并存 ;随着温度的提高 ,不同构象能快速互变 。

Aim To study the NMR phenomena of cetirizine hydrochloride and assign all proton and carbon signals in NMR spectra. Methods To record the 1D and 2D NMR spectra of cetirizine hydrochloride while changing the experimental temperature and adding D 2O into the solution. Results More than one NMR signal or broad peak resulting from piperazine and the attached groups with N atom were given in DMSO d 6 solution at room temperature. “Coalescence” or narrowing had occurred for the proton and carbon signals whe...