热休克蛋白与肿瘤的免疫治疗

Heat shock protein and tumor immunological therapy

热休克蛋白是在细胞内广泛分布、高度保守的蛋白质分子,能与细胞内多种肽分子结合,通过抗原提呈细胞上的受体,将抗原肽经MHCⅠ类途径传递给CD8^+的细胞毒T细胞,诱导特异性抗肿瘤免疫应答。HSP与肿瘤的关系已成为当前研究的热点之一,热休克蛋白肽复合物作为一种肿瘤疫苗,在肿瘤治疗方面具有广阔的应用前景。

Heat shock protein(HSPs) is a kind of protein molecule widespread and highly conservative in the cells. In the context of major histocompatibility complex(MHC) I class molecules, HSP presented peptides to CD8+ cytotoxic cells, induced specific anti-tumor immune response through binding the receptors on the surface of APC. Its relevance to tumor has been hotly debated. As a vaccine, HSP plays an important role for immunotherapy of cancer.