巨噬细胞刺激蛋白的研究进展

Macrophage stimulating protein (MSP/HGFL)

巨噬细胞刺激蛋白(MSP)主要表达于肝组织,释放于血清中,与受体RON的主要结合位点位于β链。MSP诱导细胞扩散、浸润和增殖,在肿瘤发生中具有重要作用。MSP能促进或抑制细胞凋亡,抑制iNOS(Inducible nitric oxide synthase)合成,促进皮肤损伤组织愈合,激发巨噬细胞突发性呼吸。MSP信号转导还存在于骨组织、雄性生殖系统和胚胎发育中;在人类肾脏、老鼠舌头、雄性生殖系统中新发现有MSP表达。

The multi-functional factor macrophage stimulating protein ( MSP) , is a serum protein factor belonging to the plasminogen-related Kringle protein family. As the ligand for the transmembrane receptor tyrosine kinase RON in humans or STK in mice, MSP binding to RON causes receptor tyrosine phosphorylation leading to up-regulation of RON catalytic activity and subsequent activation of downstream signaling molecules, induces cellular responses including adhesion, invasive growth, proliferation, cell scattering...