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NK细胞受体KIR2DL4的结构与功能 被引量：3

Structure and function of NK cell receptor KIR2DL4
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摘要 KIR2DL4分子是NK细胞受体(NKR)的一种,属于免疫球蛋白样(IgSF)受体家族成员,主要分布在自然杀伤(Natural killer,NK)细胞上。KIR2DL4是HLA-G分子的特异性受体,结构上具备激活性和抑制性受体的双重特点,能够通过不同途径影响NK细胞的活性,具有重要的免疫调节功能。 KIR2DL4 is a member of immunoglobulin-superfamily NK cell receptors, expressing mainly on the surface of natural killer cells. KIR2DL4 is the specific receptor for the non-classical HLA-G antigen with both the inhibitory and activating receptor characteristics. Therefore, KTR2DL4 can regulate NK cell function in different ways under a particular condition.
作者 颜卫华
机构地区 上海第二医科大学上海市免疫学研究所
出处 《免疫学杂志》 CAS CSCD 北大核心 2003年第S1期53-56,共4页 Immunological Journal
基金 国家自然科学基金(30070784) 上海市科委重点资助项目(02DJ14054)
关键词 NK细胞受体 KIR2DL4 HLA-G NK cell receptor KIR2DL4 HLA-G
分类号 R392 [医药卫生—免疫学]
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共引文献27

同被引文献30

  • 1陈春玲,廖秦平.hCG促进绒癌细胞系中HLA-G的表达[J].中国妇产科临床杂志,2004,5(2):113-115. 被引量：3
  • 2WeiHuaYAN LiAnFAN.Residues Met^(76) and Gln^(79) in HLA-G α1 domain involved in KIR2DL4 recognition[J].Cell Research,2005,15(3):176-182. 被引量：13
  • 3张文权,熊文琴,彭国庆.孕酮对早孕人滋养层HLA-G mRNA转录水平的调控[J].生殖与避孕,2005,25(7):400-403. 被引量：4
  • 4薛松果,杨珏琴,姚芳娟,许玲娣,范丽安.正常妊娠和原因不明习惯性流产者HLA-G基因14bp缺失多态性研究[J].现代免疫学,2006,26(4):318-321. 被引量：12
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免疫学杂志
2003年 第S1期

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