红细胞生成的转录调节多因子的协调作用

Interplaying of Transcription Factors in Erythropoiesis

红细胞由造血干细胞分化而成,此过程包含复杂转录因子的相互作用,这些转录因子调节下游基因的表达并介导分化与增生信号,红细胞谱系的多能干细胞的定型诱导血细胞生成.主要综述了适应红细胞发育的广谱因子及特殊因子,这些因子单独操纵或部分参与转录、激活或表达.

The differentiation of haematopoietic stem cells into various lineages involves complex interactions of transcription factors that modulate the expression of downstream genes and mediate proliferation and differentiation signals. Commitment of pluripotent haematopoietic stem cells to the erythroid lineage induces erythropoiesis. The broadspectrum factors as well as specific factors required for proper erythroid development are reviewed. These factors may operate solely or as part of transcriptional complex...