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肿瘤坏死因子受体相关因子2(TRAF2)在TNF信号传导中的作用 被引量：2

Tumor necrosis factor receptor-associated factor2(TRAF2) in TNF signaling
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摘要 肿瘤坏死因子受体相关因子(TRAFs)是经TNF受体超家族和IL-1R/TLR超家族信号传导通路的重要成分.TNF信号传导中,TRAF2作为接头蛋白和调控因子在几乎所有分支通路中起作用,在调节TNF-R1介导的NF-κB和JNK激活过程中起重要作用.近来的研究提示,TRAF2是凋亡信号传导和抗凋亡信号传导的分支点.本文主要阐述TRAF2的分子结构及它的结构与功能的关系,TNF信号传导的分子机制及TRAF2在其中的作用,重点关注TRAF2作为凋亡途径和NF-κB介导的存活途径,即这2条相互拮抗的信号传导途径的分支点的重要性. The tumor necrosis factor receptor associated factors(TRAFs) have emerged as the major signal transducers for the TNF receptor superfamily and the interleukin-1 receptor/Toll-like recepor (IL-1R/TLR) superfamily.In TNF signaling pathway,TRAF2 as adapter proteins and regulation factors are important to nearly all pathways,having a key role in mediating TNF-R1-induced activation of NF-κB and JNK.Recent studies suggest that TRAF2 represents an integration point for proand antiapoptatic signals.This review foc...
作者 徐冬蕾
机构地区 中国医学科学院中国协和医科大学医学生物学研究所
出处 《云南大学学报（自然科学版）》 CAS CSCD 2003年第S1期237-240,共4页 Journal of Yunnan University(Natural Sciences Edition)
关键词 TRAF2 信号传导 调控 TRAF2 signaling regulation
分类号 N55 [自然科学总论]
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参考文献10

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同被引文献45

  • 1张昌军,王华,周艳梅,刘浩,刘海湘,代炳梅.白细胞介素6及肿瘤坏死因子-α对体外受精-胚胎移植结局的影响[J].郧阳医学院学报,2003,22(5):257-261. 被引量：9
  • 2王国云,姜虹,晁岚,于红玲,高云红.人卵丘颗粒细胞凋亡与卵子发育潜能关系的研究[J].生殖与避孕,2006,26(2):91-94. 被引量：18
  • 3隋旭霞,罗丽莉,傅玉才,郭宪国,许铭炎,许锦阶.新生鼠卵巢FOXO3a表达水平与卵母细胞凋亡的相关性初步研究[J].生殖与避孕,2006,26(9):515-519. 被引量：13
  • 4彭如心,王启发.肿瘤坏死因子-α与卵巢内分泌功能[J].齐齐哈尔医学院学报,1996,17(3):224-225. 被引量：2
  • 5Soto P,Natzke RP,Hansen PJ.Actions of tumor necrosis factor-alpha on oocyte maturation and embryonic development in cattle.Am J Reprod Immunol,2003,50(5):380-8.
  • 6Marcinkiewicz JL,Balchak SK,Morrison LJ.The involvement of tumor necrosis factor-alpha (TNF-α) as an intraovarian regulator of oocyte apoptosis in the neonatal rat.Front Biosci,2002,7(9):1 997-2 005.
  • 7Morrison LJ,Marcinkiewicz JL.Tumor necrosis factor alpha enhances oocyte/follicle apoptosis in the neonatal rat ovary.Biol Rporod,2002,66(2):450-7.
  • 8Greenfeld CR,Roby KF,Pepling ME,et al.Tumor necrosis factor (TNF) receptor type 2 is an important mediator of TNF alpha function in the mouse ovary.Biol Reprod,2007,76(2):224-31.
  • 9ManabeN,Goto Y,Matsuda-Minehata F,et al.Regulation mechanism of selective atresia in porcine follicles:regulation of granulosa cell apoptosis during atresia.J Reprod Dev,2004,50(5):493-514.
  • 10Murdoch WJ,van Kirk EA,Murdoch J.Plasmin cleaves tumor necrosis factor alpha exodomain from sheep follicular endothelium:implication in the ovulatory process.Biod Repord,1999,60(5):1 166-71.

引证文献2

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云南大学学报（自然科学版）
2003年 第S1期

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