信使RNA研究与细胞因子类生物制药

Messenger RNA researching and biological producing of cytokines

分子生物学"中心法则"揭示了DNA→RNA→蛋白质的遗传信息流的深刻内涵,它是现代基因工程技术发展的基础.最近研究表明,信使RNA在蛋白质合成中,不但表现出一维序列上的对应,且在两者的空间构象上也表现出某些对应关系.这为细胞因子等蛋白多肽类生物制药的工艺改进提供了科学依据.

As the basis of modern genetic engineering,the"central dogma"of molecular biology manifests that genetic information is transmitted by way of"DNA→ RNA→ protein".Recently, it has been proved that an mRNA molecule instructs the corresponding protein synthesizing not only in the primary structure but also in the conformation.This important research should be a scientific foundation for improving the bioprocess technology of the biological products of the proteins such as all sorts of cytokines.