^(99)Tc^m-MIBI和^(201)Tl SPECT显像对肺癌远处转移的预测价值

The value of ^(99)Tc^m-MIBI and ^(201)Tl SPECT in predicting distant metastases in patients with lung cancer

目的 分析有无远处转移肺癌原发灶摄取和清除99Tcm 甲氧基异丁基异腈 (MIBI)和2 0 1 Tl的差异 ,探讨99Tcm MIBI和2 0 1 TlSPECT对肺癌远处转移的预测价值。方法 86例未经手术、化疗或放疗的肺癌患者行99Tcm MIBI和2 0 1 Tl双核素双时相肺断层显像 (早期相 ,注射后 10min ;延迟相 ,注射后 4h) ,利用感兴趣区 (ROI)技术 ,分别计算MIBI和2 0 1 Tl早期及延迟靶 本比值 (T N)、洗脱率 ,洗脱率 =[(早期T N -延迟T N) (早期T N) ]× 10 0 %。根据超声、放射学影像和骨显像等检查结果 ,将患者分为远处转移组 (39例 )和无远处转移组 (4 7例 ) 2组 ,采用SPSS 10 0统计软件进行统计分析。结果 远处转移组 ,MIBI早期、延迟T N和MIBI洗脱率分别为 3 0 2± 2 76、2 19± 1 0 9和 (14± 2 9) % ,无远处转移组分别为 1 98± 0 9、2 17± 1 16和 (- 14± 4 2 ) % ,远处转移组MIBI早期T N和MIBI洗脱率均明显高于无远处转移组 (P <0 0 2和P <0 0 0 1) ,两组间MIBI延迟T/N差异无显著性。远处转移组2 0 1 Tl早期T/N、2 0 1 Tl延迟T/N、2 0 1 Tl洗脱率分别为 1 87± 0 79、2 2 1± 0 86、(- 2 2± 33) % ,无远处转移组分别为1 76± 0 73、2 0 6± 0 85、(- 2 1± 37) % ,两组间差异无显著性。

Objective To evaluate the relation between 99Tcm-methoxyisobutylisonitrile (MIBI) accumulation by the tumor and its distant metastatic potential in patients with lung cancer and compare with the same parameters achieved using 201Tl. Methods Eighty-six patients with primary lung carcinoma were studied before therapy. According to the radiological, ultrosonographical and bone scan findings, the patients were classified into two groups: with distant metastases (n=39) and without distant metastases (n=47)...