人参四逆汤各部分提取物对大鼠失血性休克模型的影响

Effects of Different Extracts from Ginseng-Sini Decoction on Hemorrhagic Shock in Rats

目的:研究人参四逆汤各部分提取物对大鼠失血性休克的药理作用。方法:以失血性休克大鼠为实验对象,将动物分为对照组及人参四逆汤11个不同提取物给药组,观察人参四逆汤不同提取物对失血性休克大鼠血压、心率、生存时间及生存百分率的影响。结果:附子乙醚提取物+干姜乙醚提取物(F_7+F_8)、人参四逆汤乙醚提取物(S_1)、人参四逆汤(上柱)70%乙醇洗脱液(S_7)可缓解失血性休克,其中 F_7+F_8可使失血性休克动物血压明显升高,动物存活时间明显延长,存活百分率明显提高。结论:人参四逆汤中 F_7+F_8、S_1、S_7三个不同提取物对恢复大鼠失血性休克有明显作用。

Objective:To investigate the pharmacological effect of various extracts of Ginseng-Sini Decoction(GSSD) on hemorrhagic shock (HS) in rats.Methods:HS rats were divided into control and GSSD (11 extracts) treated group to observe the effects of extracts of GSSD on the blood pressure,heart rate,survival time,survival precentage of HS rats.Results:The ether extract of aconitum carmichaeli + ether extract of dry ginger(F_7+F_8),ether extract of GSSD (S_1),70% ether eluant of GSSD(S_7)could remit the HS,F_7+F_8 c...