君主安胶囊对实验性心律失常的影响

Effect of Junzhu' an Capsule on Experimental Arrhythmia

目的:观察君主安胶囊对实验性心律失常及各项相关指标的影响。方法:采用 CaCl_2、乌头碱、哇巴因及缺血再灌注所致心律失常模型观察药物作用。结果:君主安胶囊对4个心律失常模型有明显作用,心律失常持续时间缩短,程度减轻;对缺血再灌注所致心律失常模型,还能降低血清磷酸肌激酶(CK)、乳酸脱氢酶(LDH)及丙二醛(MDA)含量,增加血清超氧化物歧化酶(SOD)活性,增加再灌注心肌组织 Na^+、K^+-ATP 酶活性。结论:君主安胶囊对实验性心律失常有明显保护作用。

Objective:To observe the effect of Junzhu an Capsule(JZA)on experimental arrhythmia and all the related indexes.Methods: Effect of JZA was observed by arrhythmic model induced by CaCl_2,aconitine,ouabin and ischemia/reperfusion.Results:JZA had obvious function in the four models with shortened arrhythmic persistent time and lessened arrhythmic degree.In the model induced by ischemia/reperfusion,contents of serum CK,lactic dehydrogenase(LDH),malondialdehyde(MDA)were lowered,serum SOD activity was increased,N...