急性髓细胞性白血病N-ras癌基因表达的意义

Significance of N-ras Oncogene Expression in Acult Myelogenous Leukemia

目的 探讨N -ras在急性髓细胞性白血病中的表达。方法 RT -PCR法检测 10例急性髓细胞性白血病的N -ras癌基因。结果 3例呈阳性表达 ,阳性率 3 0 % ,观察 3例阳性患者的治疗反应 ,2例达完全缓解后N -ras阴性 ,1例未缓解N -ras持续阳性 ,于 4月后死亡。结论 N -ras癌基因检测对AML的诊断及预后判断有意义。

ObjectiveTo investigate the effect of N-ras oncogene expression in acute myelogenous leukemia(AML).Methods N-ras oncongene in 10 cases of AML were determined using reverse transcriptase-polymerase chain reaction(RT-PCR).Results 3/10 cases were the positive expression,the positive rates were 30%;2/3 patients were treated to complete remmision(CR).Their N-ras oncogene change negative,1/3 patients was no remmision(NR),his N-ras oncogene change negative,1/3 patient was no remmision(NR),his N-ras oncogene keep...