一叶萩碱联合山莨菪碱骨髓腔内滴注治疗再生障碍性贫血的临床研究

Combinative Study for Treatment of Aplastic Anemia of Securinine Plus Anisodamini Dripping in Bone Marrow

目的 探讨进一步提高再生障碍性贫血 (AA)疗效。方法 采用前瞻性同期对照进行研究。比较一叶碱联合 65 4-2骨髓腔内滴注 (治疗组 )和 65 4-2静滴 (对照组 )治疗AA的疗效。结果 治疗组治愈缓解率 ( 83 .3 % )和总有效率 ( 94.4% )显著高于对照组 ( 11% ,5 5 .6% ,P <0 0 0 1)。且治疗组骨髓象的恢复更为良好。结论 一叶碱联合 65 4-2骨髓腔内滴注治疗AA疗效显著 ,治愈缓解率高 。

ObjectiveTo explore more effective and lower expensive approach for aplastic anemia(AA).Methods A prospective,randomized clinical trial was conducted to determine whether the outcome of AA patients treated with the combination of securinine plus anisodamini dripping in bone marrow(therapy group)was better than that with anisodamini alone dripping in vein(control group).Results The cure remission rate(83.3%) and the response rate(94.4%) of therapy group were significantly higher than that of control group(...