摘要
目的探讨血清脑钠素(BNP)水平在评价充血性心力衰竭(CHF)中的应用价值,以及观察不同病因的心衰患者血清BNP的水平变化。方法选取100例CHF患者,并根据纽约心脏协会(NYHA)分级标准分为Ⅱ～Ⅳ级,选取100名心功能正常者为实验对照,采用全自动免疫分析仪(罗氏2010型)电化学发光法(E-CLA)测定各组HF患者血清BNP水平。结果CHF病人血清BNP为4745.49±3698.70ng/ml,高于对照组66.18±44.30ng/ml,两者相比差异具有统计学意义(P<0.05),且BNP浓度随着心功能分级的增加也增加;不同病因(高血压、冠心病、风心病)所致的CHF患者血清BNP水平(NYHAⅢ、Ⅳ级)的差异无统计学学意义(P>0.05),但NYHAⅡ级各病因组间BNP水平差异有显著性(P<0.05)。结论CHF患者血清BNP水平显著增高,且随着NYHA分级增加而增加,可作为评价CHF严重程度的客观指标。
Objective To explore the value of Brain Natriuretic peptide(BNP)in estimating the degree of seriousness of congestive heart failure(HF)and study BNP level of CHF caused by various cardiovascular diseases.Methods 100 patients with CHF were divided into three classes(class Ⅰ,Ⅱ and Ⅳ)by New York Heart Association(NYHA)functional classification Standard.100 healthy individuals were selected into control group.Serum BNP concentration were measured by electrochemical luminescence assay(Elecsys 2010,Roche Diagnost...
出处
《成都医学院学报》
CAS
2007年第Z1期174-176,183,共4页
Journal of Chengdu Medical College
关键词
脑钠素
充血性心力衰竭
血清
诊断
brain natriuretic peptide
congestive heart failure
serum
diagnosis
