雷公藤多甙对佐剂性关节炎大鼠L_5 DRG内SP、CGRP表达的影响

Effects of Polyglycosides of Tripterygium Wilfordii Hook F on the Expression of SP and CGRP in L_5 Dorsal Root Ganglion of Adjuvant Arthritis Rats Model

目的探讨雷公藤多甙(TⅡ)对佐剂性关节炎大鼠L5背根神经节(DRG)内SP、CGRP表达的影响及其作用机制。方法采用佐剂性关节炎模型大鼠,分别灌胃给予雷公藤多甙预防和治疗用药7d后,观察L5 DRG内SP、CGRP阳性神经元的分布并计数。结果TⅡ预防组和治疗组与模型组比较,L5背根神经节内SP、CGRP表达明显降低。结论雷公藤多甙可通过降低L5 DRG内SP、CGRP的表达发挥治疗作用。

Objective To explore the effects of polyglycosides of Tripterygium Wilfordii Hook F(TⅡ)on the expression of SP、CGRP in L5 dorsal root ganglion of Adjuvant Arthritis rats model.Methods Adjuvant Arthritis rats were fed by TⅡ prevention and thrapy for 7 days,to observe the number and percentage of SP、CGRP positive neurons among total neurons in bilateral DRG(L5).Results SP、CGRP expression in neurons of L5 DRG in bilateral side in TⅡ preventive group and therapeutic group decreased apparently as compared with t...