抗结核药物致肝损害116例临床分析

Clinical Analysis on 116 Cases of Liver Damage Induced by Anti-tuberculosis Drugs

目的:探讨抗结核药物对肝脏损害的特点和防治办法。方法:回顾分析我院2007年1~12月住院及门诊初治肺结核患者1440例中抗结核药物致肝损害116例的临床资料。结果:抗结核药物在不同年龄段、全程服药期间,均可发生肝损害,其发生率为8.1%(116/1440)。轻者不需停用抗结核药物,仅加用保肝药物;重者则需停用抗结核药物,并给予保肝治疗。结论:在不同年龄段和全程服药期间,抗结核药物均可发生肝损害。掌握抗结核药物致肝损害的类型、时间、程度、高危因素及防治措施,可以保证抗结核治疗的进行,提高肺结核的治疗水平。

Objective:To explore the liver damage induced by anti-tuberculosis drugs,and to identify certain regulations and control measures.Methods:Retrospective analysis was carried out on 116 tuberculosis patients suffering with liver damage induced by anti-tuberculosis drugs,who were in-patients and out-patients of our hospital during 2007.Results:The anti-tuberculosis drugs could cause liver damage at different ages during the entire medical process.The incidence of liver damage induced by anti-tuberculosis drugs...