阴道镜联合HPV16、18检测用于宫颈疾病筛查62例分析

The Analysis of Colposcopy Combined with Detection of HPV16,18 in the Diagnosis of Cervical Disease

目的:通过阴道镜联合HPV检测对于宫颈疾病筛查的研究,探讨阴道镜结合HPV16、18的检测对宫颈疾病的诊断价值。方法:采用阴道镜下对宫颈形态、有无异常血管、镶嵌、白斑等的观察,PCR法检测宫颈组织中HPV16、18亚型,并与病理检查结果对照分析。结果:62例患者中,阴道镜检查诊断可疑宫颈CIN17例,病理证实12例,其中CINⅠ3例,CINⅡ5例,CINⅢ4例,宫颈炎5例,阴道镜诊断宫颈CIN的灵敏度88.57%,特异度81.48%,阳性预测值86.11%,阴性预测值78.57%;宫颈疾病中CIN及宫颈癌HPV16、18感染率分别为75.00%、89.47%,显著高于宫颈炎性患者;阴道镜在HPV16、18感染阳性患者CIN诊断率明显高于HPV16、18感染阴性患者。结论:阴道镜可以作为宫颈疾病的筛查方法,其可以提高宫颈CIN检出的灵敏度,减少漏诊率;HPV16、18感染与宫颈CIN及宫颈癌的发生明显相关,对HPV16、18的检测可以作为筛查宫颈疾病的方法之一,与阴道镜检查结合可以提高宫颈CIN及癌变的诊断准确率。

Objective:To evaluate the value of colposcopy combined with detection of HPV16,18 in diagnosis of cervical diseases,especially in cervical intraepithelial neoplasia(CIN).Methods:Colpscopy was used to examine cervix uteri and PCR was used to test HPV16,18 DNA.Conclusion:Colposcopy is a suitable diagnostic method to screening cervical diseases,especially in CIN.Inflammation of HPV 16,18 is obviously related with CIN and cervical cancer.HPV16,18 detection can be used to diagnose CIN too.While combined with col...