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乳腺癌中VEGF-C的表达及脉管生成的临床意义 被引量：1

The Significance of VEGF-C Expression and Lymphangiogenesis/Angiogenesis in Breast Cancer
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摘要 目的探讨乳腺癌中VEGF-C的表达与肿瘤脉管生成的特点、相互关系及其临床意义。方法收集乳腺癌标本65例,采用原位杂交法检测肿瘤组织中VEGF-CmRNA的表达,采用SP免疫组织化学染色法以VEGFR-3多克隆抗体及CD34单克隆抗体分别标记肿瘤组织中淋巴管及微血管,计数淋巴管密度(LVD)及微血管密度(MVD),分析VEGF-C的表达与脉管生成及相关临床病理参数间的关系。结果VEGF-C阳性表达率为55.4%,淋巴转移组阳性率(76.2%)明显高于阴性组(45.5%),差异具有显著性(P<0.05);LVD及MVD计数分别6.3±3.0、11.6±7.0,其在转移组脉管计数(8.2±3.7、14.7±7.8)均高于无转移组(5.3±2.1、10.2±6.2),LVD计数在VEGF-C阳性组(7.2±3.4)亦高于阴性组(5.1±2.0),均具有统计学意义(P<0.05);MVD与VEGF-C表达无关,VEGF-C的表达及LVD和MVD均与患者年龄、肿块大小及临床分期无相关(P>0.05)。结论尽管VEGF-C不能促进乳腺癌中肿瘤血管生成,但是可通过诱导淋巴管生成而促进肿瘤淋巴转移,抑制VEGF-C的表达及脉管生成具有重要的治疗意义。 Objective To investigate the significance and relationship between VEGF-C expression and lymphangiogenesis/angiogenesis in breast cancer. Methods The expression of VEGF-C mRNA in 65 cases of breast cancer was detected by in situ hybridization. Lymphatic vessels and microvessels were labeled with VEGFR-3 polyclonal antibody and CD34 monoclonal antibody by SP immunohistochemistry method respectively, counted lymphatic vessel density(LVD) and microvessel density(MVD), and studied the relationship between VEGF-...
作者 李洋 文壹 黄俊辉
机构地区 湖南省人民医院普外科 中南大学湘雅医院肿瘤科
出处 《中国医疗前沿（学术版）》 2008年第2期1-2,4,共3页 China Healthcare Innovation
基金 湖南省社会发展科技项目基金资助(编号:OISSY2008-41)
关键词 VEGF-C 淋巴管生成 血管生成 淋巴转移 乳腺癌 VEGF-C Lymphangiogenesis Angiogenesis Lymphatic metastasis Breast cancer
分类号 R737.9 [医药卫生—肿瘤]
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参考文献8

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同被引文献9

  • 1尹秋伟,郭旭峰,胡国强,赵健,李希波.PTTG、VEGF-C的表达及微淋巴管密度与非小细胞肺癌临床病理特征的关系[J].中国老年学杂志,2007,27(14):1362-1366. 被引量：12
  • 2Lerut T, Coosemans W, Decker G, et al. Surgical techniques[J]. Surg. Oncol, 2005, 92 (3): 218-229.
  • 3McCarler M D, Clarke J H, Harken A H, Lymph angiogenesis is pivotal to the trials of a successful cancer metastasis [J]. Surgery,2004, 135 (2) :121-124.
  • 4Duff S E, Jeziorska M, Rosa D D, et al. Vascular endothelial growth factors and receptors in colorectal cancer: implications for anti-angiogenic therapy [J]. Eur. J. Cancer, 2006, 42 (2): 112- 117.
  • 5Kyzas P A, Cunha I W, Ioannidis J P. Prognostic significance of vascular endothelial growth factor immunohistochemical expression in head and neck squamous cell carcinoma: a meta-analysis [J]. Clin. Cancer Res, 2005, 11 (18) :1434-1440.
  • 6Ding S, Li C, Lin S, et al. Distinct roles of VEGF-A and VEGFC in tumour metastasis of gastric carcinoma [J]. Oncol Rep, 2007, 17 (2): 369-375.
  • 7Su JL, Yang PC, Shih JY, et al. The VEGF-C/Flt-4 axis promotes invasion and metastasis of cancer cells [J]. Cancer Cell, 2006, 9 (3): 209-223.
  • 8Mylona E, Alexandrou P, Mpakali A, et al.Clinicopathological and prognostic significance of vascular endothelial growth factors (VEGF) -C and-D and VEGF receptor 3 in invasive breast carcinoma [J]. Eur J Surg Oncol, 2007, 33 (3): 294-300.
  • 9王洲,刘相燕,张林,刘凡英,陈景寒.淋巴结隐匿性微转移对肺癌预后影响的前瞻性研究[J].中华胸心血管外科杂志,2003,19(4):225-228. 被引量：8

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中国医疗前沿（学术版）
2008年 第2期

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