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DJ-1基因启动子区g.168_185del的多态性与帕金森病的关系 被引量：4

Relationship between the monocyte of the g.168_185del polymorphism of the promoter in DJ-1 gene and Parkinson's disease
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摘要 目的了解DJ-1基因启动子区g.168_185del的多态性与帕金森病(PD)的关系。方法采用病例-对照研究,应用聚合酶链反应、DNA测序等技术,对湖南汉族213例PD患者和195名正常对照者的DJ-1基因g.168_185del多态性进行检测。结果g.168_185del多态在各组的基因型频率和等位基因频率比较差异无统计学意义(均P>0.05)。结论g.168_185del多态位点不是本组PD患者的患病危险因素。 Objective To understand the relationhip between the monocyte of g.168_185del polymorphism of the promoter in DJ-1 gene and Parkinson s disease (PD). Methods The case control study was made, the polymerase chain reaction (PCR) and sequence analysis were used to determine the genotype of g.168_185del polymorphism in 213 patients with sporadic PD and 195 healthy controls of Han nationality in Hunan. Result There was not statistically different in allele frequency and genotype frequency of the g.168_185del poly...
作者 柳四新 郭纪锋 易灿辉 唐北沙 谭红 张智博 周颖
机构地区 长沙市第一医院神经内科 中南大学湘雅医院神经内科 湖南师范大学医学院
出处 《临床神经病学杂志》 CAS 北大核心 2008年第4期267-269,共3页 Journal of Clinical Neurology
关键词 帕金森病 DJ-1基因 多态性 Parkinson s disease DJ-1 gene polymorphism
分类号 R742.5 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献9

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二级参考文献11

  • 1Bonifati V, Rizzu P, van Baren MJ, etal. Mutations in the DJ1 geneassociated with autosomal recessive early-onset parkinsonism. Science, 2003,299: 256-259.
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共引文献6

同被引文献21

  • 1郭纪锋,唐北沙,张玉虎,夏昆,蔡芳,潘乾,沈璐,江泓,赵国华,严新翔,曹立.常染色体隐性遗传性早发型帕金森综合征DJ1基因突变研究[J].中华医学遗传学杂志,2005,22(6):641-643. 被引量：7
  • 2洪雁,张本恕.Parkin基因多态性与帕金森病遗传易患性关系的研究[J].中国现代神经疾病杂志,2006,6(4):291-294. 被引量：10
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  • 10Eerola J,Herndez D,Launes J. Assessment of a DJ-1 (PARK7)polymorphism in Finnish PD[J].Neurology,2003.1000.doi:10.1212/01.WNL.0000083992.28066.7E.

引证文献4

二级引证文献6

临床神经病学杂志
2008年 第4期

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