摘要
目的分析儿童患者临床分离耐大环内酯类抗生素肺炎链球菌(MRSP)的分子流行病学特征及与国际流行克隆株的相关性。方法采用脉冲场凝胶电泳(PFGE)对107株MRSP行同源性分析。结果107株MRSP共有60个PFGE型,有6种PFGE型≥3株,这6种型共包含53株细菌,占总株数49.5%(53/107)。2003—2004年ermB和mefE阳性菌株中存在与国际流行株密切相关的流行克隆P5型(39.2%,20/51)。结论耐药菌株的克隆传播是2004年我院分离的MRSP流行的重要因素,2003—2004年临床分离株中ermB和mefE同时阳性的菌株经PFGE分型可能与国际流行株有关。
Objective To investigate the clonal relationship among macrolide-resistant Streptococcus pneumoniae(MRSP) strains in Children.Methods A total of 107 clinical isolates were typed by pulse field gel electrophoresis(PFGE).Results The 107 MRSP strains had 60 different PFGE types.Six PFGE types were identified in more than 3 strains,totally covering 49.5%(53/107) of all isolates.Results Indicated that there was an epidemic clone type P5(39.2%,20/51) in MRSP clinical isolates,which contained both ermB and mefE ge...
出处
《中国感染与化疗杂志》
CAS
2008年第4期297-299,共3页
Chinese Journal of Infection and Chemotherapy
关键词
肺炎链球菌
大环内酯类
分子流行病学
脉冲场凝胶电泳
Streptococcus pneumoniae
Macrolide
Molecular epidemiology
Pulse field gel electrophoresis
