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重症患者血糖控制目标的探讨 被引量:10

Evaluation of Optimal Goal of Glucose Control in Critically Ill Patients
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摘要 目的研究不同血糖控制对ICU患者临床预后相关指标的影响,探讨重症患者合理的血糖控制目标。方法对2006年5月~2007年12月共338例预计住ICU时间≥2天的患者进行随机分组,根据目标血糖控制水平分为A组(血糖控制目标4.4~6.1mmol/L,即80~110mg/dl,n=168)和B组(血糖控制目标7.2~8.3mmol/L,即130~150mg/dl,n=170),并根据不同病因分为不同亚组,应用我科2005年制定的计算机程序化血糖管理方案进行血糖控制,记录并追踪各组的血糖控制情况及预后相关指标,包括28天机械通气时间、住院时间、住ICU时间、感染发生率、住院病死率、红细胞输注量、住ICU费用,分析两种血糖控制水平对不同病因收住ICU的患者上述指标的影响。结果对于不同病因的患者,A组与B组相比,各预后指标之间的差异无显著性(P>0.05),A组低血糖(血糖<3.3mmol/L)发生率明显高于B组(1.87%vs.0.86%,P<0.01)。结论正常化血糖控制并不能进一步改善预后,而且使低血糖的风险明显增加。将血糖控制在≤8.3mmol/L是危重症患者较为安全、合理的血糖控制目标。 Objective To investigate the influence of two different levels of glucose control on ICU outcome,therefore to assess the optimal glucose control goal in ICU patients.Methods A total of 338 patients,who admitted to our ICU from May 2006 to December 2007 and anticipated to stay no less than 2 days,were randomly divided into two groups according to the target glucose-control levels:Group A:the mean blood glucose(MBG) was maintained at the level of 4.4-6.1 mmol/L(80-110 mg/dl,n=168);and Group B:MBG was maintain...
出处 《中国临床营养杂志》 2008年第4期204-208,共5页 Chinese Journal of Clinical Nutrition
关键词 重症患者 血糖 强化胰岛素治疗 预后 critically ill patients blood glucose intensive insulin therapy outcome
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参考文献14

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