香椿子抗血栓作用的实验研究

Antithrombotic Effects of Toona Sinensis Seeds

目的:观察香椿子的抗血栓作用。方法:对大鼠凝血酶原时间(PT)、大鼠活化部分凝血活酶时间(APTT)、大鼠凝血酶时间(TT)进行测定来观察香椿子对这些指标的影响。复制大鼠静脉血栓模型并称取血栓湿重来观察香椿子的抗血栓作用。对血瘀证大鼠模型血浆TXB2和6-Keto-PGF1α含量及血浆纤溶酶原激活物(t-PA)、纤溶酶原激活抑制物(PAI)含量的影响。结果:①对大鼠PT、APTT及TT的影响:香椿子三个剂量组均显著延长了大鼠PT及TT。980 mg/kg剂量组与生理盐水组比较能显著延长大鼠的APTT;②对大鼠血栓湿重的影响:香椿子700、980 mg/kg剂量组的血栓湿重与空白对照组比较均有显著性差异;③对血瘀证大鼠模型血浆TXB2和6-Keto-PGF1α含量的影响:香椿子水煎液对血浆TXB2含量并无明显影响。而香椿子中、高剂量组能显著升高血浆6-Keto-PGF1α含量;④对血瘀证大鼠模型血浆纤溶酶原激活物(t-PA)、纤溶酶原激活抑制物(PAI)含量的影响:香椿子水煎液各组与生理盐水组均无统计学差异。结论:香椿子有较强的抗血栓作用。

Objective: To observe the antithrombotic effects of Toona sinensis seeds.Methods: This experiment has been finished in Three Gorges University medicine central lab from Mar.2006 to Mar.2007.In each experiment,rats are separated randomly,10 each group.Tested by prothrombin time(PT),activated partial thromboplastin time(APTT),thrombin time(TT)of rats to observe the antithrombotic effect of Toona sinensis seeds.Weigh the wet thrombus of rat inferior vena cava throm model to observe the antithrombotic effects o...