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神经生长因子促进骨折愈合的临床应用 被引量:6

Preliminary Clinical Observation on Effect of Nerve Growth Factor for Healing of Fracture
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摘要 目的:探讨神经生长因子(NGF)局部注射促进骨折愈合的临床作用。方法:自2005年1月~2008年1月,对68例四肢新鲜骨折患者进行骨折端经皮局部注射NGF促进骨折愈合的临床治疗观察,其中胫腓骨骨折21例、股骨骨折16例、尺桡骨骨折20例、肱骨骨折11例。据骨折类型、治疗方法相同或相似的原则设立相应的对照组,对骨痂生长情况、骨折临床愈合的时间进行对比研究分析。结果:两组病例均获随访,时间为3~20个月,两组骨痂出现的时间、骨痂量的多少两周内无明显不同,3周后骨痂量治疗组多于对照组,治疗组各类型骨折临床愈合时间均较对照组有不同程度的缩短,疗效优于对照组,经统计学处理,P<0.01,两组对比有极显著差异。结论:临床应用神经生长因子经皮局部注射在骨折中后期有促进骨折愈合修复的作用。 Objective: To evaluate the effect of percutaneous injection with nerve growth factor(NGF) for healing of fracture in clinical.Methods: From January 2005 to January 2008,68 cases of long bone fracture were treated by percutaneous injection with NGF in clinical in our hospital,incluing 21 cases of tibial and(or) fibular fracture,16 cases of femoral shaft fracture,20 cases of ulna radius fracture,11 cases of humeral fracture.The results of fracture healing time were compared between the control group and the t...
出处 《实用医学进修杂志》 2008年第3期-,共4页 Journal of Practical Training of Medicine
关键词 神经生长因子 骨折愈合 局部注射 nerve growth factor(NGF) fracture healing percutaneous injection
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同被引文献64

  • 1马昕,黄钢勇,姜建元,吕飞舟.不同神经损伤对骨折前期愈合影响的实验研究[J].中国矫形外科杂志,2005,13(10):761-763. 被引量:12
  • 2刘宇鹏,赵德伟,吕德成,崔旭,王卫明,孙强.神经生长因子在大鼠骨折部位的表达[J].中国临床康复,2006,10(17):107-109. 被引量:26
  • 3于立明,张伟,吴亚东,王子莹.神经生长因子受体(TrkA)在下颌骨骨折愈合中的表达及意义的研究[J].中国实验诊断学,2006,10(7):768-770. 被引量:12
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