摘要
目的分析急性混合细胞白血病(HAL)的临床和实验室特征以及疗效和预后。方法根据骨髓细胞形态学、免疫表型和遗传学分析结果采用兼顾髓、淋两系治疗方案化疗。结果6例临床表现可有发热、淋巴结肿大、脾大、肝大等,所有患者骨髓增生明显活跃,近半数患者属高白细胞白血病。行免疫表型检测同时表达髓系、B系、T系者1例,同时表达髓系、T系者1例,同时表达髓系、B系者4例。染色体检查有异常核型,但未见到有特异性诊断意义的染色体改变。结论HAL较为特殊,诊断有赖于对细胞形态学、化学染色和尤其是免疫分型的综合判断。对HAL的治疗应该给予兼顾髓、淋二系的诱导和巩固化疗方案。但长期疗效的评价还有待进一步观察。
Objective To analyze the clinical and laboratorial features of hybrid acute leukemia(HAL),as well as the effect of chemotherapy and the prognosis of HAL.Methods HAL was diagnosed according to the results of morphology,cytochemistry and immunophenotyping of bone marrow cells,and was treated with the regimen in-volving both myeloid and lymphoid lineag.Results Clinical presentation of six HAL patients included fever,enlarge-ment of lymph node,spleen and/or liver.Marrows of all the patients were markedly hyperc...
出处
《中国血液流变学杂志》
CAS
2008年第3期341-343,共3页
Chinese Journal of Hemorheology
关键词
急性混合细胞白血病
免疫分型
预后
Hybrid acute leukemia（HAL）
Immunological classification
Prognosis
