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强制性运动疗法对脑缺血后神经元轴突再生及Nogo-A蛋白水平影响的研究 被引量：9

The Effects of Constraint-induced Movement Therapy on the Axonal Regeneration and the Expression of Nogo-A Protein
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摘要 目的探讨强制性运动疗法对脑缺血后神经元轴突再生及Nogo-A蛋白水平的影响。方法应用免疫组化及Western blot方法并结合行为学观察强制性运动疗法对脑缺血后神经元轴突再生及Nogo-A蛋白的表达的影响。结果脑缺血后强制性运动疗法能够促进患侧肢体运动功能的恢复,促进皮质脊髓束的再生,并能降低脑组织Nogo-A蛋白的表达水平。结论强制性运动疗法可能通过影响脑缺血后的神经再生过程从而增强中枢神经系统的修复能力。 Objective To investigate the effects of constraint-induced movement therapy (CIMT) on axonal regeneration and the expression of Nogo-A protein after stroke. Method This study investigated the effects of CIMT on axonal regeneration and the expression of Nogo-A protein using immunohistochemistry and Western blot combined with behavioral tests. Result The results demonstrated that following stroke,CIMT can improve the functional recovery,enhance the axonal regeneration and decrease the expression of Nogo-A pro...
作者 戚其学 李玉芬 赵珊珊 聂莹雪 赵传胜
机构地区 中国医科大学附属第一医院神经免疫室 中国医科大学附属第一医院神经内科
出处 《中国血液流变学杂志》 CAS 2008年第3期317-319,340,共4页 Chinese Journal of Hemorheology
基金 国家自然科学青年基金资助项目(30500611) 教育部留学回国人员科研启动基金资助项目(教外司留[2006]331号)
关键词 脑缺血 强制性运动疗法 轴突再生 NOGO-A Constraint-induced movement therapy axonal regeneration stroke Nogo-A
分类号 R743.3 [医药卫生—神经病学与精神病学]
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参考文献12

  • 1[1]Dombovy ML.Understanding stroke recovery and rehabilitation:Current and emerging approaches[J].Curt Neurol Neurosci Rep,2004,4:31-35.
  • 2[2]Dettmers C,Teske U,Hamzei F,et al.Distributed form of constraint-induced movement therapy improves functional outcome and quality oflife after stroke[J].Arch Phys Med Rehabil,2005.86:204-209.
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中国血液流变学杂志
2008年 第3期

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