妊娠高血压综合征患者血浆11-去氢-血栓烷B_2测定及其临床意义

Detection of Plasma 11-dehydrothromboxane B_2 in Patients with Pregnancy Induced Hypertension and Its Clinical Significane

目的观察妊娠高血压综合征(PIH)患者体内血小板活化状态。方法采用酶联免疫吸附法(ELISA)检测38例PIH患者血浆11-去氢-血栓烷B2(DH-TXB2),同时测定TXB2,并与正常未孕组比较。结果与正常未孕组及正常孕妇组比较,PIH患者血浆DH-TXB2、TXB2均显著增高(P<0.01及P<0.05),且DH-TXB2增高程度明显高于TXB2,中、重度PIH患者血浆DH-TXB2显著高于正常妊娠及轻度PIH组。结论血浆DH-TXB2水平测定是准确反映血小板活化的指标,PIH患者体内血小板高度活化。

Objective To investigate the platelet activation in patients with pregnancy induced hypertension (PIH).Method Plasma 11-dehydrothromboxane B2(DH-TXB2) and thromboxane B2(TXB2) were detected using ELISA in 38 PIH patients and 20 normal non-pregnant women.Results The concentrations of plasma DH-TXB2 and TXB2 in PIH patients were significantly increased compared with those of normal pregnant women and normal non-pregnant women (P<0.01,P<0.05),and the degree of increased plasma DH-TXB2 was much higher tha...