辛伐他汀对心脏X综合征患者内皮功能及血液流变学的影响

The Effects of Simvastatin on Hemorheology and Endodermis Function of X-syndrome Patient

目的研究辛伐他汀与传统药物相结合对心脏X综合征患者的内皮功能及血液流变学影响。方法选择2006年10月～2007年10月40例临床拟诊心脏X综合征的患者进行临床资料分析及干预,按照就诊顺序随机分为他汀组和对照组,每组20例,对照组常规给予β受体阻滞剂、钙通道阻滞剂或长效的硝酸酯类治疗,他汀组在对照组基础上联合辛伐他汀40mg,每晚1次,随访12周后,观察临床情况。结果他汀组疼痛发作次数较治疗前显著减少,血清ET水平、血浆粘度和ET/NO显著降低,血清NO水平显著升高;与对照组治疗后比较血清ET-1水平及ET/NO明显降低,疼痛次数明显减少,血清NO明显升高;疼痛次数与ET/NO呈正相关。结论辛伐他汀对心脏X综合征患者能有效地改善患者的内皮功能和血液流变学,有较好的临床治疗作用。

Objective To study the therapeutic effect of hemorheology and the endodermis function with simvastatin and traditional medicine on patients with X-syndrome,and the serum ET-1、NO、ET/NO.Methods 40 patients with X-syndrome were recruited from October 2006 to October 2007 and randomly divided into two groups (simvastatin group and control group).The control group received routine treatment including β receptor blocker,CCB and long active nitrate.The simvastatin group received simvastatin and the rountine treatm...