立体定位多靶点联合损毁治疗难治性精神分裂症83例分析

The therapeutics effect on intractable schizophrenia by bilateral stereotactic multiple target radiofrequency lesion technique

目的:探讨选择性双侧多靶点毁损术治疗难治性精神分裂症的疗效。方法:应用脑立体定向技术对83例难治性精神分裂症进行颅内选择性双侧多靶点毁损治疗。结果:83例患者术后随访恢复20例,占24.1%;显著进步41例,占49.4%;进步14例,占16.9%;无变化8例,占9.6%;总有效率为90.4%。BPRS评分术前明显高于术后(P<0.05)。MMSE评定手术前后无显著性差异(P>0.05)。术后无严重并发症和后遗症。结论:立体定位多靶点联合损毁治疗可安全、有效治疗难治性精神分裂症。根据患者个体症状决定相应的多靶点组合,对提高疗效、降低并发症有较大意义。

Objective:To investigate the clinical effects of bilateral stereotactic multiple targets radiofrequency lesion in patients with intractable schizophrenia. Methods: 83 cases of intractable schizophrenia were treated with radiofrequency thermocoagulation of bilateral multiple nuclei by using stereotactic technique. Results: After the operation, 20 patients were cared, 41 patients were significantly improved, 14 patients were improved, 8 patients were unchanged. The total effective rate was 90.4%. Significant ...