颅脑损伤术后镇静镇痛的应用及效果评价

Application and evaluation of sedative and analgesic in craniocerebral injury patients after surgery

目的:评价颅脑损伤术后应用咪达唑仑与芬太尼镇静镇痛治疗的效果及其安全性。方法:选择ICU颅脑损伤术后46例需行镇静镇痛治疗的患者,均持续静脉泵入小剂量咪达唑仑与芬太尼,在给药前及给药后15min及药物持续状态下记录患者呼吸频率、平均动脉压、动脉血氧饱和度及心率变化,评价联合应用小剂量咪达唑仑与芬太尼的治疗效果及观察药物不良反应。结果:患者的呼吸频率、平均动脉压、动脉血氧饱和度及心率在用药前后无显著性差异(P>0.05);患者的镇静镇痛评分明显好转,基本可达治疗目标;不良反应发生较少,且均给予及时处理。结论:小剂量咪达唑仑和芬太尼对ICU颅脑损伤术后患者有良好的镇痛镇静效果,联合应用可消除机械通气患者的焦虑及人机对抗。

Objective:To investigate the efficacy of midazolam and fentanyl in craniocerebral injury patients after surgery.Methods: 46 patients needed sedative and analgesic after craniocerebral injury surgery in intensive care unit were collected,they were all given minimum dosage fentanyl and midazolam intravenous, the respiratory rate(R), mean arterial blood pressure(MAP), saturation of arterial blood oxygen(SpO2), heart rate(HR) were observed before and after 15 minutes treatment, to evaluation the therapeutic eff...