毛细支气管炎患儿吸入激素治疗后血清皮质醇的变化

The effect of glucocorticoid inhalation on serum cortisol in children with bronchiolitis

目的:探讨吸入布地奈德早期干预毛细支气管炎(毛支)对减少哮喘发病率的影响及血清皮质醇水平的动态变化。方法:将75例毛支患儿临床缓解后随机分为两组,干预组33例(失访3例)吸入布地奈德3个月,未干预组42例(失访13例)不再用药。两组病人干预前测定血清皮质醇基础值,12周后复查。以21例无喘息症状的同龄儿为正常对照组。结果:112周后干预组30例血清皮质醇虽有一定程度的下降,但与未干预组29例相比无显著性差异(P>0.05)。2随访至1年时干预组哮喘发病率(16.7%)低于未干预组(44.83%),两者相比有显著性差异(P<0.05)。干预组喘息复发率(30%)低于未干预组(58.62%),两组相比有显著性差异(P<0.05)。结论:毛支患儿早期吸入激素干预治疗可降低哮喘发病率,对肾上腺皮质功能无明显影响。

Objective:To investigate the effect of inhaling budesonide on decreasing the incidence of asthma after bronchiolitis and to observe the dynamic change of serum cortisol during treating with inhaling budesonide. Methods: 75 cases with bronchiolitis after clinical remission were divided into two groups randomly and the levels of serum cortisol were tested. One group (n=33) had inhaled budesonide for three months and the other(n=42) had not inhaled. Serum cortisol test were repeated after 12 weeks. 21 cases wi...