尼莫地平联合阿米替林治疗脑卒中后抑郁的临床观察

Effect of Nimodipine combined Amitriptyline on depressive state of post-stroke patients

目的探讨尼莫地平联合阿米替林对PSD的疗效。方法我院住院患者100例,随机分为观察组及对照组各50例,对照组患者给予口服阿米替林,观察组患者阿米替林加用尼莫地平。分别于治疗前和治疗后8周,采用HAMD、MMSE、CSS、MBI评价2组疗效。结果2组患者疗效间差异有统计学意义(P<0.05),观察组患者治疗前后差异有统计学意义(P<0.01),2组患者治疗后HAMD、MMSE、CCS、MBI评分间差异有统计学意义(P<0.05),对照组患者治疗前后HAMD、MMSE评分间差异有统计学意义(P<0.01)。结论尼莫地平联合阿米替林对脑卒中后抑郁治疗有效,并能够改善患者的认知能力及神经功能缺损,提高日常生活活动能力,改善预后。

Objective To evaluate the efficacy of nimodipine combined amitriptyline on depressive state of post-stroke patients.Methods 100 post-stroke patients were randomly divided into the amitriptyline group( 50cases) and the nimodipine combined amitriptyline group( 50 cases) , clinical progress was monitored with HAMD、MMSE、CSS and Barthel index before and after 8 weeks treatment.Results After 8 weeks treatment the total effective rate of depressive in the treatment group and control group were 86% and 64%, there w...