摘要
超氧化物歧化酶是一种广泛存在于动物、植物、微生物中的金属酶,按其结合的金属离子可分为Fe SOD、Mn SOD、CuZn SOD三种,它们催化超氧阴离子自由基O·-2 发生歧化反应,从而清除O·-2 ,因而它能防御氧毒性,增强机体抗辐射损伤能力,防衰老,在一些肿瘤、炎症、自身免疫疾病等治疗中有良好疗效.本文对SOD的分布与定位,理化特性及结构,SOD分子修饰与SOD模拟酶。
SOD is a metal enzyme which broadly exists in animals, plants, and microorganisms. It contains Fe-SOD?Mn-SOD and CuZn-SOD which cause the disproportionation of superoxide anion radicals, O ·- _2, to take place by catalyzing so as to clean O ·- _2. Therefore, it can guard against oxygen poison, strengthen resistance to radiation damage and delay senility. It has good cure effects in some tumors, inflammatory diseases and self-immunity diseases. In this article, we provide a survey of the fields in SOD's distribution and position, its physical, chemical features and structure, SOD molecular decoration, SOD mimetic enzyme, SOD gene cloning and expression and SOD future use.
出处
《淮阴师范学院学报(自然科学版)》
CAS
2002年第4期82-86,共5页
Journal of Huaiyin Teachers College;Natural Science Edition