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非小细胞肺癌患者血清可溶性细胞间粘附分子-1的水平及临床意义 被引量：2

Serum levels of soluble intercellualr adhesion molecule-1 in patients with non-small cell lung cancer and its clinical significance
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摘要 目的　研究非小细胞肺癌 (NSCLC)患者血清可溶性细胞间粘附分子 - 1(sICAM - 1)水平的临床意义。方法　收集 5 1例不同TNM分期的NSCLC患者血清 ,双夹心ELISA法检测sICAM - 1水平。结果　NSCLC组血清sICAM - 1水平显著高于健康对照组 ,并与肺癌的临床分期有关。结论　sICAM - 1对肺癌的发展、转移有重要意义 。 Objective To investigate the clinical significance of serum sICAM-1 level in patients with NSCLC.Methods Sera from 51 cases with different TNM stages of NSCLC were collected and analyzed for concentration of sICAM-1 with Sandwich ELISA method.Results Serum levels of sICAM-1 were significantly higher in NSCLC group than in healthy controls and correlated with the clinical stage of NSCLC cases.Conclusions sICAM-1 could be an important factor which underlies tumor invasion and metastasis and may have a prognostic value in lung cancer.
作者 施敏骅 胡筠珠 胡华成
机构地区 苏州大学附属第二医院呼吸内科
出处 《中国实用内科杂志》 CAS CSCD 北大核心 2002年第2期80-81,共2页 Chinese Journal of Practical Internal Medicine
关键词 非小细胞肺癌 可溶性细胞间粘附分子-1 NSCLC sICAM-1
分类号 R5 [医药卫生—内科学]
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参考文献3

  • 1[1]Stolpe A,Saag PT.Intercellular adhesion molecule - 1.J Mol Med,1996,74( 1 ): 13 -33
  • 2[2]Grothey A,Heistermann P,Philippou S,et al.Serum levels of soluble intercellular adhesion molecule - 1 ( ICAM - 1 CD54 ) in patients with non - small cell lung cancer: correlation with histological expression of ICAM - 1 and tumour stage.Br J Cancer,1998,77 ( 5 ):801 - 807
  • 3[3]Sprenger A,Schardt C,Rotsch M,et al.Soluble intercellular adhesion molecule - 1 in patients with lung cancer and benign lung diseases.J Cancer Res Clin Onco1,1997,123( 11 -12) :632 -638

同被引文献16

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中国实用内科杂志
2002年 第2期

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