痘苗病毒载体与肿瘤基因治疗

VACCINIA VIRUS VECTOR AND TUMOR GENE THERAPY

随着基因治疗的发展 ,痘苗病毒载体由于具有可表达多种外源基因、毒性低、可制备高滴定度的重组病毒等特点 ,日益受到重视。综述了重组痘苗病毒载体的构建及其特性。已构建了表达多种细胞因子及肿瘤抗原的rVV 。

As the development of gene therapy, vaccinia virus has increasingly attracted more attention since its such excellent characters as high expression of foreign genes, low toxicity, and easy preparation of recombinant virus with high titer etc. The construction of vaccinia virus vector and its characters were reviewed in this paper. An rVV vector expressed many cell factors and tumor antigens have been constructed, which could enhance host anti tumor immunity.\;